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Pediatr Infect Dis J. 2002 Sep;21(9):887-8.

Herpes simplex virus colitis in a neonate.

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  • 1Departments of Immunology and Infectious Diseases, Royal Alexandra Hospital for Children, Westmead, Australia.


Involvement of the gastrointestinal tract in neonates with congenital herpes simplex virus (HSV) infection is rarely described. We report a case of a newborn with disseminated HSV infection associated with profuse hematochezia and late sigmoid colon perforation. Histologic examination showed patchy areas of ulceration with multinucleated giant cells and HSV nucleic acid was detected by polymerase chain reaction in colonic tissue. No clinically apparent episodes of recurrent colitis occurred in the first year of life.

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