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Nat Neurosci. 2002 Nov;5(11):1242-7.

Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma.

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  • 1Research Service, Veterans Administration Medical Center, 718 Smyth Road, Manchester, New Hampshire 03104, USA. mark.gilbertson@med.va.gov

Abstract

In animals, exposure to severe stress can damage the hippocampus. Recent human studies show smaller hippocampal volume in individuals with the stress-related psychiatric condition posttraumatic stress disorder (PTSD). Does this represent the neurotoxic effect of trauma, or is smaller hippocampal volume a pre-existing condition that renders the brain more vulnerable to the development of pathological stress responses? In monozygotic twins discordant for trauma exposure, we found evidence that smaller hippocampi indeed constitute a risk factor for the development of stress-related psychopathology. Disorder severity in PTSD patients who were exposed to trauma was negatively correlated with the hippocampal volume of both the patients and the patients' trauma-unexposed identical co-twin. Furthermore, severe PTSD twin pairs-both the trauma-exposed and unexposed members-had significantly smaller hippocampi than non-PTSD pairs.

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PMID:
12379862
[PubMed - indexed for MEDLINE]
PMCID:
PMC2819093
Free PMC Article

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