Format

Send to:

Choose Destination
See comment in PubMed Commons below
Presse Med. 2002 Sep 14;31(29):1383-5.

[A new mechanism of action of chondroitin sulfates ACS4-ACS6 in osteoarthritic cartilage].

[Article in French]

Author information

  • 1Service de rhumatologie du Pr Vignon, CH Lyon Sud, 165, chemin du Grand Revoyet, 69495 Pierre-Bénite. pierre-.mathieu.rhumato@wanadoo.fr

Abstract

THE MECHANISMS OF ACTION ALREADY KNOWN:

In vitro, chondroïtin sulfate ACS4-ACS6 have a dose-dependent inhibiting effect on the catabolism of proteoglycanes and collagen. They also stimulate the synthesis of extracellular matrix macromolecules. The existence of a chondrocyte cyto-protector effect and a potentially chondro-protective effect has also been demonstrated.

ANOTHER MECHANISM OF ACTION:

A new regulation route of chondrocyte metabolism has been proposed in which the Insulin Growth Factor (IGF-1) impedes the catabolic effects of another cytokine, Interleukin 1 (IL-1), by increasing its antagonistic receptor. This control appears essential in the maintenance extracellular matrix homeostasis.

CARTILAGE WITH OSTEOARTHRITIS:

Chondrocytes from OA cartilage have the capacity to produce more constituting macromolecules of the extracellular matrix. Conversely, these same cells have a greater catabolic capacity. The enhanced activity of IL-1 and the concomitant decrease in its antagonistic receptors leads to the reduction in macromolecule levels in the extracellular matrix, produced in the Cell-associated matrix of OA chondrocytes.

ANTI-CATABOLIC EFFECT:

It has been demonstrated that ACS4-ACS6 are capable of neutralizing the enhanced catabolic capacity of activated human OA chondrocytes.

PMID:
12375394
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk