Nature. 2002 Oct 10;419(6907):583-6.

Somatic cell nuclear transfer.

Wilmut I, Beaujean N, de Sousa PA, Dinnyes A, King TJ, Paterson LA, Wells DN, Young LE.

Source

Roslin Institute, Roslin, Midlothian EH25 9PS, UK. ian.wilmut@bbsrc.ac.uk

Abstract

Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.

PMID:: 12374931; [PubMed - indexed for MEDLINE]

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