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Free Radic Biol Med. 2002 Oct 15;33(8):1021-5.

Protein oxidation during aging of the nematode Caenorhabditis elegans.

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  • 1Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.


The nematode Caenorhabditis elegans has proven a robust genetic model for studies of aging, including the roles of oxidative stress and protein damage. In this review, we focus on the genetics of select long-lived (e.g., age-1, daf-2, daf-16) and short-lived (e.g., mev-1) mutants that have proven useful in revealing the relationships that exist among oxidative stress, life span, and protein oxidation. The former are known to control an insulin/IGF-1-like pathway in C. elegans, while the latter affect mitochondrial function.

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