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Bioorg Med Chem Lett. 2002 Nov 4;12(21):3027-31.

Novel semi-synthetic glycopeptide antibiotics active against methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE): doubly-modified water-soluble derivatives of chloroorienticin B.

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  • 1Discovery Research Laboratories, Shionogi & Co., Ltd., Sagisu 5-12-4, Fukushima-ku, 553-0002, Osaka, Japan.

Abstract

A series of N-alkylated and aminomethylated derivatives of chloroorienticin B, a vancomycin-related glycopeptide antibiotic, were synthesized. Doubly-modified derivatives having both hydrophobic and hydrophilic substituents exhibited potent antibacterial activity against MRSA and VRE along with considerable water-solubility.

PMID:
12372494
[PubMed - indexed for MEDLINE]
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