Transcription activation: unveiling the essential nature of TFIID

Curr Biol. 2002 Sep 17;12(18):R620-2. doi: 10.1016/s0960-9822(02)01134-x.

Abstract

The TAF subunits of TFIID mediate activation of subsets of the eukaryotic genome. Recent results demonstrate that TFIID is recruited to promoters in an activator-specific manner involving functional interaction between upstream regulatory elements and the core promoter, thereby coordinating the expression of distinct sets of genes.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Macromolecular Substances
  • Models, Biological
  • Protein Subunits
  • TATA-Binding Protein Associated Factors / chemistry
  • TATA-Binding Protein Associated Factors / genetics
  • TATA-Binding Protein Associated Factors / physiology
  • Transcription Factor TFIID / chemistry
  • Transcription Factor TFIID / genetics*
  • Transcription Factor TFIID / physiology*
  • Transcriptional Activation*

Substances

  • Macromolecular Substances
  • Protein Subunits
  • TATA-Binding Protein Associated Factors
  • Transcription Factor TFIID