Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Genome Biol. 2002 Sep 19;3(10):reviews1029. Epub 2002 Sep 19.

Variations in abundance: genome-wide responses to genetic variation and vice versa.

Author information

  • Department of Medicine (Division of Genetics), Department of Cellular and Molecular Medicine, and Rebecca and John Moores UCSD Cancer Center, University of California San Diego School of Medicine, La Jolla, CA 92093-0644, USA. bah@ucsd.edu


How do naturally occurring polymorphisms in DNA sequence relate to variation in gene expression? Recent work to map genetic sources of expression variation has shown a surprising balance between cis and trans effects. Other work suggests some chromosomal clustering of genes by expression pattern. A synthesis of approaches may provide new insight in to adaptive mechanisms in evolution and the population basis of complex traits.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk