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Genome Biol. 2002 Sep 16;3(10):reviews1027. Epub 2002 Sep 16.

Large-scale gene-expression studies and the challenge of multiple sclerosis.

Author information

  • 1Department of Neurology, University of California San Francisco, San Francisco, CA 94143-0435, USA. sebaran@cgl.ucsf.edu

Abstract

In multiple sclerosis, a complex neurodegenerative disorder, a combination of genetic and environmental factors results in inflammation and myelin damage. Recent transcription-profiling studies have found distinct gene-expression patterns in diseased tissue; such large-scale studies at different stages of the disease are contributing to understanding multiple sclerosis and developing effective therapy.

PMID:
12372148
[PubMed - indexed for MEDLINE]
PMCID:
PMC244911
Free PMC Article

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