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Vox Sang. 2002 Oct;83(3):279-81.

Transfusion-associated graft-versus-host disease in a patient with Waldenstrom's macroglobulinaemia.

Author information

  • 1Department of Haematology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK. laura@cosmics.force9.co.uk

Abstract

BACKGROUND AND OBJECTIVES:

Routine irradiation of cellular blood products is not presently recommended for patients with non-Hodgkin's lymphoma (NHL).

MATERIALS AND METHODS:

We report the case of a 72-year-old-man with Waldenstrom's macroglobulinaemia who developed transfusion-associated graft-versus-host disease (TA-GvHD) 13 days following a non-irradiated red cell transfusion.

RESULTS:

The patient had not previously received purine analogues and none of the donors was homozygous for a human leucocyte antigen (HLA) haplotype that was shared by the recipient. Therefore, his only apparent risk factor was lymphoplasmacytoid NHL.

CONCLUSIONS:

This case further strengthens the argument that NHL per se is a risk factor for TA-GvHD and supports the proposal that the guidelines for prophylactic irradiation of cellular blood products be extended to include all cases of NHL.

PMID:
12366774
[PubMed - indexed for MEDLINE]
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