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J Am Geriatr Soc. 2002 Oct;50(10):1698-701.

Preoperative supraphysiological testosterone in older men undergoing knee replacement surgery.

Author information

  • 1Department of Medicine, VA Puget Sound Health Care System, Seattle, Washington, USA. jamory@u.washington.edu

Abstract

OBJECTIVES:

Older patients undergoing knee replacement surgery can recover more slowly than younger patients and require extended rehabilitation. Because administration of supraphysiological testosterone (T) dramatically increases strength, we hypothesized that preoperative T therapy would improve functional recovery and reduce hospital stay in older men undergoing knee replacement surgery.

DESIGN:

Double-blinded, placebo-controlled pilot trial.

SETTING:

A Veterans Affairs orthopedics clinic and inpatient postoperative unit.

PARTICIPANTS:

Twenty-five men, mean age 70, undergoing elective knee replacement.

INTERVENTION:

Preoperative, supraphysiological T administration (600 mg T enanthate intramuscularly weekly for 4 weeks) or sesame oil placebo.

MEASUREMENTS:

Length of hospital stay and functional ability by Functional Independence Measure (FIM) score.

RESULTS:

Mean length of hospital stay +/- standard deviation was nonsignificantly reduced in the T group (5.9 +/- 2.4 days vs 6.8 +/- 2.5 days; P =.15). At postoperative Day 3, there was a significant improvement in ability to stand (mean FIM score 5.2 +/- 1.0 vs 4.0 +/- 1.1; P =.04) and trends towards improvements in walking and stair climbing in the T group. There were no complications attributable to T therapy.

CONCLUSIONS:

In older men undergoing knee replacement surgery, preoperative supraphysiological T administration may confer some clinical benefit. Future studies using longer courses of preoperative T administration in larger numbers of older men undergoing knee replacement surgery are warranted.

PMID:
12366624
[PubMed - indexed for MEDLINE]
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