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Science. 2002 Oct 4;298(5591):176-8.

G protein-coupled receptors in Anopheles gambiae.

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  • 1Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.

Abstract

We used bioinformatic approaches to identify a total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation.

PMID:
12364795
[PubMed - indexed for MEDLINE]
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