Abstract
Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition of the pro-inflammatory cytokine TNF-alpha produced by monocytes.
MeSH terms
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Drug Therapy, Combination
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Erythema Nodosum / drug therapy
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Erythema Nodosum / pathology
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Humans
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Incidence
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Leprostatic Agents / therapeutic use*
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Leprosy / drug therapy*
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Leprosy / pathology
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Leprosy / transmission
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Leprosy, Lepromatous / drug therapy
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Leprosy, Lepromatous / pathology
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Models, Molecular
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Mycobacterium leprae / pathogenicity
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Thalidomide / adverse effects
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Thalidomide / pharmacokinetics
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Thalidomide / pharmacology
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Thalidomide / therapeutic use*
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Leprostatic Agents
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Tumor Necrosis Factor-alpha
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Thalidomide