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Microbes Infect. 2002 Sep;4(11):1149-56.

Iron acquisition by Gram-positive bacterial pathogens.

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  • 1Department of Infectious Diseases, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Flowers Building, Armstrong Road, SW7 2AZ, London, UK. jerry.brown@ic.ac.uk

Abstract

For the majority of bacterial pathogens, acquisition of iron from host proteins is a prerequisite for growth during infection. The mechanisms by which Gram-negative bacteria obtain iron from host proteins have been well described, but only recently has substantial progress been made in identifying these mechanisms for Gram-positive bacterial pathogens. This review provides an overview of the existing knowledge on the genetic basis of iron transport for important Gram-positive pathogens.

PMID:
12361915
[PubMed - indexed for MEDLINE]
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