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Microbes Infect. 2002 Sep;4(11):1149-56.

Iron acquisition by Gram-positive bacterial pathogens.

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  • 1Department of Infectious Diseases, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Flowers Building, Armstrong Road, SW7 2AZ, London, UK.


For the majority of bacterial pathogens, acquisition of iron from host proteins is a prerequisite for growth during infection. The mechanisms by which Gram-negative bacteria obtain iron from host proteins have been well described, but only recently has substantial progress been made in identifying these mechanisms for Gram-positive bacterial pathogens. This review provides an overview of the existing knowledge on the genetic basis of iron transport for important Gram-positive pathogens.

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