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1: J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 5;779(2):307-12.Click here to read Links

High-performance liquid chromatographic method for the determination of gabapentin in human plasma.

Zhu Z, Neirinck L.

Pharmascience, 6111 Royalmount Avenue, Suite 100, Montreal Quebec, H4P 2T4, Canada. zzhu@pharmascience.com

A sensitive high-performance liquid chromatography (HPLC) method using UV detection for the determination of gabapentin in human plasma has been developed. In this method, gabapentin was extracted from human plasma with a reversed-phase solid-phase extraction (SPE) cartridge followed by derivatization with phenylisothiocyanate. Analysis was achieved by using a HPLC system that was equipped with a UV detector. The quantitation limit of gabapentin in human plasma was 0.03 microg/ml. The method is sensitive with excellent selectivity and reproducibility and it has been applied to a bioequivalence clinical study with great success.

PMID: 12361744 [PubMed - indexed for MEDLINE]

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    Gabapentin is used to help control certain types of seizures in patients who have epilepsy. Gabapentin is also used to relieve the pain of postherpetic neuralgia (PHN; the burning, stabbing pain or aches that may last fo...

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