My NCBI | Sign In
RSS Settings
  • Search:

Display Settings:

Format

Send to:

Choose Destination

    J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 5;779(2):307-12.

    High-performance liquid chromatographic method for the determination of gabapentin in human plasma.

    Zhu Z, Neirinck L.

    Pharmascience, 6111 Royalmount Avenue, Suite 100, Montreal Quebec, H4P 2T4, Canada. zzhu@pharmascience.com

    A sensitive high-performance liquid chromatography (HPLC) method using UV detection for the determination of gabapentin in human plasma has been developed. In this method, gabapentin was extracted from human plasma with a reversed-phase solid-phase extraction (SPE) cartridge followed by derivatization with phenylisothiocyanate. Analysis was achieved by using a HPLC system that was equipped with a UV detector. The quantitation limit of gabapentin in human plasma was 0.03 microg/ml. The method is sensitive with excellent selectivity and reproducibility and it has been applied to a bioequivalence clinical study with great success.

    PMID: 12361744 [PubMed - indexed for MEDLINE]

    MeSH Terms, Substances

    MeSH Terms:

    Substances:

    LinkOut - more resources

    Full Text Sources:

    Libraries:

    Supplemental Content

    Click here to read

    Related articles

    Patient drug information

    • Gabapentin (Gabarone®, Neurontin®)

      Gabapentin is used to help control certain types of seizures in patients who have epilepsy. Gabapentin is also used to relieve the pain of postherpetic neuralgia (PHN; the burning, stabbing pain or aches that may last fo...

    • Source: AHFS Consumer Medication Information

    All links from this record

    • Related Articles

      Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.

    • Compound (MeSH Keyword)

      PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

    • Substance (MeSH Keyword)

      PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

    Recent activity