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Nat Rev Immunol. 2002 Oct;2(10):725-34.

NF-kappaB regulation in the immune system.

Author information

  • 1The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

Erratum in

  • Nat Rev Immunol 2002 Dec;2(12):975.

Abstract

The nuclear factor-kappaB (NF-kappaB)/REL family of transcription factors has a central role in coordinating the expression of a wide variety of genes that control immune responses. There has been intense scientific activity in the NF-kappaB field owing to the involvement of these factors in the activation and regulation of key molecules that are associated with diseases ranging from inflammation to cancer. In this review, we focus on our current understanding of NF-kappaB regulation and its role in the immune system and inflammatory diseases. We also discuss the role of NF-kappaB proteins as potential therapeutic targets in clinical applications.

PMID:
12360211
[PubMed - indexed for MEDLINE]
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