Your browser version may not work well with NCBI's Web applications. More information here...
1: Int J Clin Pharmacol Ther. 2002 Sep;40(9):422-3.Links

A case of nonarteritic ischemic optic neuropathy (NAION) in a male patient taking sildenafil.

Boshier A, Pambakian N, Shakir SA.

Drug Safety Research Unit, Southampton, UK.

Sildenafil is a phosphodiesterase-type-5 inhibitor indicated for the treatment of erectile dysfunction in men. We report a case of NAION identified from a cohort of 8,893 patients (from a Prescription-Event Monitoring study) prescribed sildenafil by their primary care physician in England between April and June 1999. This 61-year-old patient had risk factors for NAION independent of drug therapy. It was not possible to be confident about a causal association between sildenafil and NAION, though the possibility could not be ruled out. Epidemiological data suggest that one case of NAION might be expected in a cohort of 8,893 subjects. Thus it remains important for clinicians to consider the range of risk factors for NAION; while equally, the processes of pharmacovigilance need to continue as for any recently launched drug preparation.

PMID: 12358159 [PubMed - indexed for MEDLINE]

Related Articles

Patient Drug Information
  • Sildenafil (Revatio®, Viagra®) Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Revatio) is used to improve the ability to exercise in people with pulmonary arterial hypert...
    » read more ...