J Clin Microbiol. 2002 Oct;40(10):3822-5.

Assessment of a combined testing strategy for detection of antibodies to human herpesvirus 8 (HHV-8) in persons with Kaposi's sarcoma, persons with asymptomatic HHV-8 infection, and persons at low risk for HHV-8 infection.

Casper C, Krantz E, Taylor H, Dalessio J, Carrell D, Wald A, Corey L, Ashley R.

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Department of Medicine, Virology Research Clinic, University of Washington School of Medicine, Box 359928, Seattle, WA 98195, USA. ccasper@u.washington.edu

Abstract

The performance of a human herpesvirus 8 (HHV-8) enzyme immunoassay (EIA) and selective subsequent use of an HHV-8 immunofluorescence assay (IFA) was tested in persons unlikely to be infected with HHV-8 and those who had HHV-8 detected in their saliva. The IFA was performed on samples within a range of EIA optical densities (0.15 to 0.35) where there was considerable overlap between HHV-8-infected and uninfected individuals. The sensitivity of the testing strategy was 88%, with a specificity of 97%.

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PMCID:: PMC130660

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Research Support, U.S. Gov't, P.H.S.

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Antibodies, Viral

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Assessment of a combined testing strategy for detection of antibodies to human herpesvirus 8 (HHV-8) in persons with Kaposi's sarcoma, persons with asymptomatic HHV-8 infection, and persons at low risk for HHV-8 infection.
J Clin Microbiol. 2002 Oct ;40(10):3822-5.

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