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Curr Opin Microbiol. 2002 Oct;5(5):499-505.

Functional and evolutionary analysis of a eukaryotic parasitic genome.

Author information

  • 1Parasitologie Moléculaire et Cellulaire, LBP - UMR CNRS 6023, Université Blaise Pascal, 63117 Aubiere Cedex, France.

Abstract

The DNA sequences of the 11 linear chromosomes of the approximately 2.9 Mbp genome of Encephalitozoon cuniculi, an obligate intracellular parasite of mammals, include approximately 2000 putative protein-coding genes. The compactness of this genome is associated with the length reduction of various genes. Essential functions are dependent on a minimal set of genes. Phylogenetic analysis supports the hypotheses that microsporidia are related to fungi and have retained a mitochondrion-derived organelle, the mitosome.

PMID:
12354558
[PubMed - indexed for MEDLINE]
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