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J Org Chem. 2002 Oct 4;67(20):7138-9.

AlCl(3) x 6H(2)O/KI/H(2)O/CH(3)CN: a new alternate system for dehydration of oximes and amides in hydrated media.

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  • 1Organic Chemistry Division, Regional Research Laboratory, Jorhat 785 006, Assam, India.


Dehydration of oximes and amides to nitriles was carried out using the AlCl(3) x 6H(2)O/KI/H(2)O/CH(3)CN system. It produced isoquinoline derivatives 8a-c (Bischler Naperialski reaction) when reacted with amides 7a-c in hydrated media. Also, the keto oximes produced anilides (Beckmann rearrangement) with the system under the same reaction conditions.

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