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Hum Mol Genet. 2002 Oct 1;11(20):2507-15.

Gene finding in genetically isolated populations.

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  • 1Institute of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.


The struggle to identify susceptibility genes for complex disorders has stimulated geneticists to develop new approaches. One approach that has gained considerable interest is to focus on genetically isolated populations rather than on the general population. There remains much controversy and theoretical debate over the feasibility and advantages of such populations, but recent results speak in favor of the feasibility of this approach, and will be reviewed here.

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