Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biophys J. 2002 Oct;83(4):1834-41.

Red blood cells augment leukocyte rolling in a virtual blood vessel.

Author information

  • 1Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA.

Abstract

Leukocyte rolling and arrest on the vascular endothelium is a central event in normal and pathological immune responses. However, rigorous estimation of the fluid and surface forces involved in leukocyte-endothelial interactions has been difficult due to the particulate, non-Newtonian nature of blood. Here we present a Lattice-Boltzmann approach to quantify forces exerted on rolling leukocytes by red blood cells in a "virtual blood vessel." We report that the normal force imparted by erythrocytes is sufficient to increase leukocyte binding and that increases in tangential force and torque can promote rolling of previously adherent leukocytes. By simulating changes in hematocrit we show that a close "envelopment" of the leukocyte by the red blood cells is necessary to produce significant changes in the forces. This novel approach can be applied to a large number of biological and industrial problems involving the complex flow of particulate suspensions.

PMID:
12324405
[PubMed - indexed for MEDLINE]
PMCID:
PMC1302276
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk