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    Med Hypotheses. 2002 Jun;58(6):487-90.

    Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy.

    McCarty MF.

    Pantox Laboratories, San Diego, Californi 92109, USA.

    Glucomannan (GM) is differentiated from other soluble fibers by the extraordinarily high viscosity of GM solutions. Administration of 4-5g of GM with meals, blended into fluid or mixed with food, can slow carbohydrate absorption and dampen the postprandial insulin response by up to 50%. Controlled clinical studies document that GM can promote satiety and weight loss, lower LDL cholesterol, improve diabetic control, and correct constipation, with minimal if any side-effects. Rodent studies suggest that GM may have potential for decreasing cancer risk and possibly even slowing the ageing process. Hepatothermic therapy, a technique for achieving rapid loss of body fat by optimizing the liver's capacity for fat oxidation, can only achieve its optimal efficacy if diurnal insulin levels are kept low; ingestion of GM with meals will evidently be of benefit in this regard by moderating postprandial insulin surges.

    PMID: 12323114 [PubMed - indexed for MEDLINE]

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