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Neurology. 2002 Sep 24;59(6):954-5.

Therapy-related acute myeloblastic leukemia after mitoxantrone treatment in a patient with MS.

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  • 1Department of Neurology, Hôpital Purpan, Toulouse University Medical Center, Toulouse, France. dbrassat@yahoo.fr


The authors report a patient with severe secondary progressive MS who responded to mitoxantrone but developed a fatal acute myeloblastic leukemia 15 months after completion of mitoxantrone therapy. Therapy-related acute leukemia (TRAL) in relation with mitoxantrone is rare; this patient was the first case among a cohort of 802 French MS patients treated with mitoxantrone. Nevertheless, this case stresses the need to further evaluate the long-term risk of TRAL in patients with MS who receive mitoxantrone.

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