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Neurology. 2002 Sep 24;59(6):932-4.

Predictors of effective bilateral subthalamic nucleus stimulation for PD.

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  • 1Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France.


To identify factors predictive of effective bilateral subthalamic nucleus (STN) stimulation for PD with severe motor complications, pre- and postoperative Unified PD Rating Scale (UPDRS) scores were analyzed in a series of 54 patients who received bilateral STN stimulation. Younger age and levodopa responsiveness predict a favorable response to bilateral STN stimulation. For individual PD symptoms, those that improve with a suprathreshold dose levodopa challenge are likely to improve with stimulation.

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