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FEBS Lett. 2002 Sep 25;528(1-3):17-22.

The eye photoreceptor protein rhodopsin. Structural implications for retinal disease.

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  • 1Secció de Terrassa, Departament d'Enginyeria Qui;mica, Universitat Politècnica de Catalunya, Colom 1, 08222 Terrassa, Catalonia, Spain. pere.garriga@upc.es

Abstract

Rhodopsin is the membrane receptor responsible for photoreception in the vertebrate retina. Its characteristic seven-transmembrane helical structural motif is today widely recognised as a paradigm in signal transduction. Rhodopsin and the phototransduction system are frequently used as structural and mechanistic models for the G-protein coupled receptor superfamily. Recent advances in the activation mechanism (as derived from the structural available data) and the implications for normal and pathological - in retinal disorders - visual function will be reviewed.

PMID:
12297272
[PubMed - indexed for MEDLINE]
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