-
Transplantation of islets of Langerhans in diabetic rhesus monkeys.
Islets of Langerhans from unrelated donor rhesus monkeys were transplanted into the portal vein of five rhesus monkeys which had been made diabetic by partial pancreatectomy and Streptozotocin. There was definite improvement of the diabetic state with an increase in the mean KT1/2 from 0.71 to 1.52 percent per minute. The islets were isolated by a more efficient digestion-filtration process than previously had been described. This process has allowed, for the first time, successful isolation of large masses of islets permitting islet transplants in subhuman primates.
PMID: 122797 [PubMed - indexed for MEDLINE]
-
Cited by 5 PubMed Central articles
-
ReviewPancreatic islet transplantation.
Naftanel MA, Harlan DM.
PLoS Med. 2004 Dec; 1(3):e58; quiz e75.
[PLoS Med. 2004]
-
Survival of isolated human islets of Langerhans maintained in tissue culture.
Andersson A, Borg H, Groth CG, Gunnarsson R, Hellerström C, Lundgren G, Westman J, Ostman J.
J Clin Invest. 1976 May; 57(5):1295-301.
[J Clin Invest. 1976]
-
ReviewTransplantation of insulin-secreting tissues.
Karl RC, Scharp DW, Ballinger WF, Lacy PE.
Gut. 1977 Dec; 18(12):1062-72.
[Gut. 1977]
- » See all...