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Holoprosencephaly: birth data, benetic and demographic analyses of 30 families.
Thirty families were studied to determine genetic and evnironmental factors involved in holoprosencephaly. Those with chromosomal abnormalities were excluded. Many factors appear to cluster in proband families, such as mental retardation, mental illness, endocrine disorders, increased twinning and poverty level socioeconomic status. The empiric recurrence risk was 6%. Among 7 with lobar holoprosencephaly, there were 3 females and 4 males, while there were 19 females and 6 males with alobar holoprosencephaly.
PMID: 1227533 [PubMed - indexed for MEDLINE]
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Cited by 8 PubMed Central articles
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ReviewHoloprosencephaly.
Dubourg C, Bendavid C, Pasquier L, Henry C, Odent S, David V.
Orphanet J Rare Dis. 2007 Feb 2; 2:8. Epub 2007 Feb 2.
[Orphanet J Rare Dis. 2007]
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Cebocephaly, alobar holoprosencephaly, spina bifida, and sirenomelia in a stillbirth.
Chen CP, Shih SL, Liu FF, Jan SW.
J Med Genet. 1997 Mar; 34(3):252-5.
[J Med Genet. 1997]
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Holoprosencephaly in the west of Scotland 1975-1994.
Whiteford ML, Tolmie JL.
J Med Genet. 1996 Jul; 33(7):578-84.
[J Med Genet. 1996]
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