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    Yeast. 2002 Oct;19(14):1261-76.

    Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6.

    Rodríguez-Navarro S, Llorente B, Rodríguez-Manzaneque MT, Ramne A, Uber G, Marchesan D, Dujon B, Herrero E, Sunnerhagen P, Pérez-Ortín JE.

    Source

    Departamento de Bioquímica y Biología Molecular, Universitat de València, C/Dr Moliner 50, E-46100, Burjassot, Spain.

    Abstract

    In order to clarify their physiological functions, we have undertaken a characterization of the three-membered gene families SNZ1-3 and SNO1-3. In media lacking vitamin B(6), SNZ1 and SNO1 were both required for growth in certain conditions, but neither SNZ2, SNZ3, SNO2 nor SNO3 were required. Copies 2 and 3 of the gene products have, in spite of their extremely close sequence similarity, slightly different functions in the cell. We have also found that copies 2 and 3 are activated by the lack of thiamine and that the Snz proteins physically interact with the thiamine biosynthesis Thi5 protein family. Whereas copy 1 is required for conditions in which B(6) is essential for growth, copies 2 and 3 seem more related with B(1) biosynthesis during the exponential phase.

    Copyright 2002 John Wiley & Sons, Ltd.

    PMID:
    12271461
    [PubMed - indexed for MEDLINE]

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