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Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13148-53. Epub 2002 Sep 23.

The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts.

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  • 1The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. ipaulsen@tigr.org

Abstract

The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.

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PMID:
12271122
[PubMed - indexed for MEDLINE]
PMCID:
PMC130601
Free PMC Article

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