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    Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13148-53. Epub 2002 Sep 23.

    The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts.

    Source

    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. ipaulsen@tigr.org

    Abstract

    The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.

    Comment in

    PMID:
    12271122
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC130601
    Free PMC Article

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