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Brain Res. 2002 Oct 4;951(2):336-40.

Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker.

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  • 1Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA. st9d@virginia.edu

Abstract

Voltage-gated Ca(2+) channels play a crucial role in pain perception. We studied the antinociceptive potential of systemically administered mibefradil, a peripherally acting antihypertensive agent and preferential T-type Ca(2+) channel blocker. Systemic injections of mibefradil, in clinically relevant doses, induced mechanical and thermal antinociception in adult rats without compromising their sensorimotor abilities. This suggests that peripherally acting T-type Ca(2+) channel blockers can be useful antinociceptive agents.

PMID:
12270514
[PubMed - indexed for MEDLINE]
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