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Am J Med Genet. 2002 Oct 1;112(2):215-6.

Association of nonsyndromic Wilms tumor with premature centromere division (PCD).

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  • 1MTA-PTE Research Group of Clinical Genetics, University of Pécs, Hungary.


Wilms tumor was discovered in a 22-month-old otherwise healthy girl. Her pretreatment karyotype proved to be normal 46,XX with total premature division (PCD) in 21% of her lymphocyte mitoses. This phenomenon was not seen in the parents. PCD was found in less than 4% of lymphocyte mitoses of five other children with Wilms tumor. The individual finding provides further evidence for a relation of PCD to tumorigenesis; however, elucidation of the question needs further systematic studies.

Copyright 2002 Wiley-Liss, Inc.

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