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J Virol. 2002 Oct;76(20):10507-11.

Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection.

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  • 1Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI 53715, USA. tallen2@partners.org

Abstract

Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.

PMID:
12239328
[PubMed - indexed for MEDLINE]
PMCID:
PMC136573
Free PMC Article

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