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Antimicrob Agents Chemother. 2002 Oct;46(10):3308-10.

Antimicrobial properties of milk: dependence on presence of xanthine oxidase and nitrite.

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  • 1Centre for Research in Biomedicine, University of the West of England, Bristol, United Kingdom. john.hancock@uwe.ac.uk

Abstract

Human and bovine milk inhibited the metabolic activity of Escherichia coli, as shown by luminescence monitoring of constructs expressing the luxCDABE genes. Inhibition was dependent on both xanthine oxidase (XO) activity and on the presence of nitrite, implying that XO-generated nitric oxide functions as an antibacterial agent.

PMID:
12234868
PMCID:
PMC128785
[PubMed - indexed for MEDLINE]
Free PMC Article
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