Exp Clin Psychopharmacol. 2002 Aug;10(3):276-85.

Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorder.

Brady KT, Sonne SC, Malcolm RJ, Randall CL, Dansky BS, Simpson K, Roberts JS, Brondino M.

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Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Carolina 29401, USA. bradyk@musc.edu

Abstract

Studies investigating carbamazepine (CBZ) in the treatment of cocaine dependence have been inconsistent. In this study, cocaine-dependent individuals with (n = 57) and without (n = 82) affective disorder were compared in a 12-week, double-blind, placebo-controlled trial. Urine drug screens (UDS) and self-report of drug use were collected weekly. Affective symptoms were measured monthly. Subjects receiving CBZ attended more medication sessions (p = .03). The CBZ-treated affective group had a trend toward fewer cocaine-positive UDS (p = .08) and a significantly longer time to first cocaine use (p = .06). CBZ treatment did not have any impact on cocaine use in individuals without affective disorders.

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