J Geriatr Psychiatry Neurol. 2002 Fall;15(3):175-9.

Hashimoto's encephalopathy in the elderly: relationship to cognitive impairment.

Galluzzi S, Geroldi C, Zanetti O, Frisoni GB.

Source

Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio-FBF, Brescia, Italy.

Abstract

Hashimoto's encephalopathy (HE) is a steroid-responsive encephalopathy associated with high titers of antithyroid antibodies. To date, 57 pediatric-, adult-, and elderly-onset cases have been described in the literature. The clinical picture is pleomorphic, and cognitive impairment is a frequently reported symptom. We report the case of a patient with slowly progressive cognitive impairment possibly caused by HE. The issue of the differential diagnosis with primary dementia is discussed. A review of cases of HE showing cognitive deterioration is also presented, and factors possibly related to characteristics of cognitive impairment and outcome after therapy are considered.

PMID:: 12230088; [PubMed - indexed for MEDLINE]

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[A patient with Hashimoto's encephalopathy showing subacute global cognitive dysfunction]. [Rinsho Shinkeigaku. 2003]
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