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Applications of InterPro in protein annotation and genome analysis.
Biswas M,
O'Rourke JF,
Camon E,
Fraser G,
Kanapin A,
Karavidopoulou Y,
Kersey P,
Kriventseva E,
Mittard V,
Mulder N,
Phan I,
Servant F,
Apweiler R.
EBI, Hinxton, Cambridge, UK.
The applications of InterPro span a range of biologically important areas that includes automatic annotation of protein sequences and genome analysis. In automatic annotation of protein sequences InterPro has been utilised to provide reliable characterisation of sequences, identifying them as candidates for functional annotation. Rules based on the InterPro characterisation are stored and operated through a database called RuleBase. RuleBase is used as the main tool in the sequence database group at the EBI to apply automatic annotation to unknown sequences. The annotated sequences are stored and distributed in the TrEMBL protein sequence database. InterPro also provides a means to carry out statistical and comparative analyses of whole genomes. In the Proteome Analysis Database, InterPro analyses have been combined with other analyses based on CluSTr, the Gene Ontology (GO) and structural information on the proteins.
PMID: 12230037 [PubMed - indexed for MEDLINE]
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Cited by 6 PubMed Central articles
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The Gene Ontology Annotation (GOA) Project-Application of GO in SWISS-PROT, TrEMBL and InterPro.
Camon E, Barrell D, Brooksbank C, Magrane M, Apweiler R.
Comp Funct Genomics. 2003; 4(1):71-4.
[Comp Funct Genomics. 2003]
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Gene Ontology annotation quality analysis in model eukaryotes.
Buza TJ, McCarthy FM, Wang N, Bridges SM, Burgess SC.
Nucleic Acids Res. 2008 Feb; 36(2):e12. Epub 2008 Jan 10.
[Nucleic Acids Res. 2008]
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Association algorithm to mine the rules that govern enzyme definition and to classify protein sequences.
Chiu SH, Chen CC, Yuan GF, Lin TH.
BMC Bioinformatics. 2006 Jun 15; 7:304. Epub 2006 Jun 15.
[BMC Bioinformatics. 2006]
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