Immunol Cell Biol. 2002 Oct;80(5):484-8.

The interplay of dendritic cell subsets in systemic lupus erythematosus.

Palucka AK, Banchereau J, Blanco P, Pascual V.

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Baylor Institute for Immunology Research and University of Texas Southwestern Medical Center, Dallas 75204, USA. karolinap@baylorhealth.edu

Abstract

Dendritic cells (DC) control immunity and tolerance. Hence, we surmised that systemic lupus erythematosus (SLE), a systemic autoimmune disease with autoreactive T and B cells, might be due to DC alterations. Based on our findings, we are proposing a model of SLE where autoimmune responses are driven by unabated activation of myeloid DC through IFN-alpha produced by plasmacytoid DC. Thus, interplay between DC subsets might represent a key component of SLE pathogenesis.

PMID:: 12225385; [PubMed - indexed for MEDLINE]

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