Phys Rev Lett. 2002 Sep 23;89(13):138101. Epub 2002 Sep 9.

Period-doubling instability and memory in cardiac tissue.

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Department of Biomedical Sciences and Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA.

Abstract

Theoretical studies have indicated that alternans (period-doubling instability) of action potential duration is associated with a restitution relation with a slope >or=1. However, recent experimental findings suggest that the slope of the restitution relation is not necessarily predictive of alternans. Here, we compared a return map memory model to action potential data from an ionic model and found that the memory model reproduced dynamics that could not be explained by a unidimensional restitution relation. Using linear stability analysis, we determined the onset of the alternans in the memory model and confirmed that the slope of the restitution curve was not predictive.

PMID:: 12225067; [PubMed - indexed for MEDLINE]

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HL62543/HL/NHLBI NIH HHS/United States

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