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Biochim Biophys Acta. 2002 Sep 19;1572(2-3):294-316.

I-type lectins.

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  • 1Glycobiology Research and Training Center, University of California, San Diego, 9500 Gilman Drive, 0687, La Jolla CA 92093-0687, USA.


The immunoglobulin superfamily is a large category of proteins defined by their structural similarity to immunoglobulins. The majority of these proteins are involved in protein-protein binding as receptors, antibodies or cell adhesion molecules. The I-type lectins are a subset of the immunoglobulin superfamily that are capable of carbohydrate-protein interactions. There are I-type lectins recognizing sialic acids, other sugars and glycosaminoglycans. The occurrence, structure, binding properties and (potential) biological functions of the I-type lectins are reviewed here.

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