Format

Send to:

Choose Destination
See comment in PubMed Commons below
Arch Neurol. 2002 Sep;59(9):1415-20.

Dementia in Parkinson disease: a proton magnetic resonance spectroscopy study.

Author information

  • 1Department of Psychiatry and Clinical Psychobiology, ICMSN, Hospital Clinic, Casanova 143, 08036 Barcelona, Spain.

Abstract

BACKGROUND:

Magnetic resonance spectroscopy has been shown to be useful in differentiating idiopathic Parkinson disease (PD) from atypical parkinsonian syndromes such as progressive supranuclear palsy, multiple system atrophy, and corticobasal degeneration.

OBJECTIVE:

To systematically investigate the utility of proton magnetic resonance spectroscopy in distinguishing between idiopathic PD with dementia (PDD) and without dementia.

DESIGN:

Group comparisons and correlations of brain metabolites with clinical and neuropsychological variables.

PATIENTS AND METHODS:

Metabolite concentrations were acquired from voxels localized to the basal ganglia and occipital cortex in 14 patients diagnosed as having idiopathic PDD, 12 patients with PD without dementia, and 13 matched control subjects. The 3 groups underwent clinical and neuropsychological assessment.

RESULTS:

In the occipital region, N-acetylaspartate levels were significantly reduced in the PDD group relative to the PD and control groups. N-acetylaspartate values correlated with neuropsychological performance but not with severity of motor impairment.

CONCLUSIONS:

N-acetylaspartate reduction in occipital lobes may be a marker for dementia in PD. The distribution of metabolite reduction differs from that reported in Alzheimer disease. These findings suggest that proton spectroscopy may serve as a metabolic marker of cognitive disturbance in patients with PD.

PMID:
12223027
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk