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    Regul Pept. 2002 Oct 15;108(2-3):165-73.

    Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP.

    Laburthe M, Couvineau A.

    Source

    Neuroendocrinology and Cell Biology, INSERM U41O, Faculté de Médecine Xavier Bichat, 75018, Paris, France. laburhe@bichat.inserm.fr

    Abstract

    VIP and PACAP are two prominent neuropeptides which share two common G protein-coupled receptors VPAC1 and VPAC2 while PACAP has an additional specific receptor PAC1. This paper reviews the present knowledge regarding three aspects of VPAC receptors including: (i). receptor specificity towards natural VIP-related peptides and pharmacology of synthetic agonists or antagonists; (ii). receptor signaling; (iii). molecular basis of ligand-receptor interaction as determined by site-directed mutagenesis, construction of receptor chimeras and structural modeling.

    PMID:
    12220741
    [PubMed - indexed for MEDLINE]

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