Your browser version may not work well with NCBI's Web applications. More information here...
1: Bioorg Med Chem Lett. 2002 Oct 7;12(19):2695-8.Click here to read Links

Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

Vanheusden V, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S.

Laboratory for Medicinal Chemistry (FFW), Ghent University, Harelbekestraat 72, B-9000 Gent, Belgium.

A number of 2'- and 3'-modified thymidine 5'-O-monophosphate analogues were synthesized as potential leads for new anti-mycobacterial drugs. Evaluation of their affinity for Mycobacterium tuberculosis thymidine monophosphate kinase showed that a 2'-halogeno substituent and a 3'-azido function are the most favorable leads for further development of potent inhibitors of this enzyme.

PMID: 12217356 [PubMed - indexed for MEDLINE]