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J Postgrad Med. 2002 Apr-Jun;48(2):117-8.

Clinical profile of leptospirosis in South gujarat.

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  • 1Department of Medicine, Government Medical College, Surat - 395 001, Gujarat, India.

Abstract

BACKGROUND:

South Gujarat has been witnessing increasing incidence of leptospirosis for the last few years.

AIM:

To study the clinical profile of leptospirosis in South Gujarat.

SETTINGS AND DESIGN:

Prospective study during July-September 2000 at the New Civil Hospital, Surat, Gujarat.

PATIENTS AND METHODS:

All the consecutive cases with clinical suspicion of leptospirosis were screened for lgM antileptospira antibody on the first and the fourteenth day. A four fold or greater increase in agglutinin antibody titre on paired samples was considered diagnostic. If the patient died before the fourteenth day then initial titre greater than 1:15 was considered diagnostic.

RESULTS:

Total number of patients referred to the hospital were fifty, of which thirty-eight [33 males, with age 14-50 (30 +/- 10.51)] were diagnosed as having leptospirosis. Most common organs involved were liver (27, 71.05%) and kidney (24, 63.15%). Cardio-vascular (12, 31.5%), pulmonary (10, 26.35%), neurological (2, 5.26%) and haematological (8, 21%) involvements were less common. Six patients died because of pulmonary involvement in the form of alveolar haemorrhage, while one died because of cardiac involvement.

CONCLUSION:

Liver and kidney were the most commonly involved organs in severe leptospirosis. Pulmonary involvement, though uncommon, led to high mortality.

PMID:
12215693
[PubMed - indexed for MEDLINE]
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