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Fertil Steril. 2002 Sep;78(3):550-6.

Spontaneous pregnancies in couples who discontinued intracytoplasmic sperm injection treatment: a 5-year follow-up study.

Author information

  • 1Center for Reproductive Medicine, Dutch-Speaking Brussels Free University, Belgium. osmanagaglu@hotmail.com

Abstract

OBJECTIVE:

To analyze the occurrence of deliveries after spontaneous conception in patients who have discontinued unsuccessful intracytoplasmic sperm injection (ICSI) treatment.

DESIGN:

Cohort follow-up study.

SETTING:

Tertiary referral center.

PATIENT(S):

Between July 1992 and December 1993, 200 Belgian women younger than 37 years underwent 433 consecutive unsuccessful ICSI cycles with freshly ejaculated sperm and eventually discontinued their treatment.

INTERVENTION(S):

Ultrasound-guided oocyte retrieval and ICSI.

MAIN OUTCOME MEASURE(S):

Delivery after 25 weeks following a spontaneous pregnancy.

RESULT(S):

The mean age at the time of the last oocyte pick-up was 31.0 +/- 3.9 years. The mean time interval between the last ICSI and the end of the follow-up period was 47.7 +/- 12.1 months. Twenty-three spontaneous pregnancies ending in delivery after 25 weeks were observed (11.5%). The cumulative delivery rate reached a plateau of 10% after 36 months of follow-up. The mean time interval (from last oocyte retrieval) for spontaneous pregnancy to occur after discontinuing ICSI treatment was 20.2 +/- 13.7 months. Proportional hazards analysis showed that delivery rate was reduced by 2.0% per year of infertility.

CONCLUSION(S):

This study suggests that duration of infertility appears to be predictive of the likelihood of live delivery after spontaneous conception following an unsuccessful ICSI treatment.

PMID:
12215332
[PubMed - indexed for MEDLINE]
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