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Biochim Biophys Acta. 2002 Sep 13;1577(2):276-86.

Transcript elongation on a nucleoprotein template.

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  • 1Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064, USA.


Chromatin forms a general, repeating barrier to elongation of transcripts by eukaryotic RNA polymerases. Recent studies of nucleosome structure and histone modifications reveal a set of likely mechanisms for control of elongation through chromatin. Genetic and biochemical studies of transcription have identified a set of accessory factors for transcript elongation by RNA polymerase II (Pol II) that appear to function in the context of chromatin. The C-terminal repeated domain (CTD) of Pol II may also play a role in regulating elongation through chromatin.

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