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J Immunol Methods. 2002 Oct 1;268(1):21-8.

MHC/peptide tetramer-based studies of T cell function.

Author information

  • 1MRC Human Immunology Unit, The Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK. xiaoning@molbiol.ox.ac.uk


Direct visualization and quantification of antigen-specific T cells using major histocompatibility complex (MHC)/peptide tetramer technology offers a powerful means to study specific T cell populations of interest. In combination with functional assays, this technology has already provided many new insights into several long-standing immunological concepts in basic science as well as clinical settings.

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