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Intensive Care Med. 2002 Sep;28(9):1220-5. Epub 2002 Jul 19.

Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis.

Author information

  • 1Department of Surgery, Division of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, P.O. Box 340, 00029/HUS, Helsinki, Finland. ville.pettila@hus.fi

Abstract

OBJECTIVE:

To evaluate the performance of procalcitonin (PCT), interleukin-6 (IL-6), C-reactive protein, leukocyte count, D-dimer, and antithrombin III at onset of septic episode and 24 h later in prediction of hospital mortality in critically ill patients with suspected sepsis.

DESIGN AND SETTING:

Prospective, cohort study in two university hospital intensive care units.

PATIENTS:

61 critically ill patients with suspected sepsis.

MEASUREMENTS AND RESULTS:

The outcome measure was hospital mortality. Hospital survivors ( n=41) and nonsurvivors ( n=20) differed statistically significantly on day 1 (admission) in PCT, IL-6, SOFA score, and APACHE II score, and 24 h later in PCT, IL-6, and D-dimer values. AT III, CRP, and leukocyte count did not differ. The areas under receiver operating curves showed reasonable discriminative power (>0.75) in predicting hospital mortality only for day 2 IL-6 (0.799) and day 2 PCT (0.777) values which were comparable to that of APACHE II (0.786), and which remained the only independent predictor of mortality.

CONCLUSIONS:

Admission and day 2 IL-6, and day 2 PCT, and day 2 D-dimer values differed significantly between hospital survivors and nonsurvivors among critically ill patients with suspected sepsis. However, in prediction of hospital mortality, only the discriminative power of day 2 PCT and IL-6 values, and APACHE II was reasonable as judged by AUC analysis (>0.75).

PMID:
12209268
[PubMed - indexed for MEDLINE]
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