Nat Rev Cancer. 2002 Sep;2(9):647-56.

The Bcl2 family: regulators of the cellular life-or-death switch.

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The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia. cory@wehi.edu.au

Abstract

Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed by proteases called caspases. The Bcl2 family of intracellular proteins is the central regulator of caspase activation, and its opposing factions of anti- and pro-apoptotic members arbitrate the life-or-death decision. Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective therapeutic approaches.

PMID:: 12209154; [PubMed - indexed for MEDLINE]

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