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Nat Rev Drug Discov. 2002 Sep;1(9):727-30.

The druggable genome.

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  • 1Molecular Informatics, Structure and Design Department, Pfizer Global Research & Development, Sandwich, Kent, CT13 9NJ, UK.

Abstract

An assessment of the number of molecular targets that represent an opportunity for therapeutic intervention is crucial to the development of post-genomic research strategies within the pharmaceutical industry. Now that we know the size of the human genome, it is interesting to consider just how many molecular targets this opportunity represents. We start from the position that we understand the properties that are required for a good drug, and therefore must be able to understand what makes a good drug target.

PMID:
12209152
[PubMed - indexed for MEDLINE]
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